Between 3-8% of the population has been estimated to have metal allergies. Many of these people need a TJA but may not be candidates because of metal sensitivity. ²¹

The maximum nickel content for cobalt chrome can be as high as 1% compared to 0.1% for titanium alloy. The nickel content of OXINIUM components cannot be detected.

Surgeons now have a better alternative for patients who report nickel sensitivity.

Superior Biocompatibility ²²

Like titanium, zirconium is one of the most biocompatible elements.

The biocompatibility of the OXINIUM material was confirmed by testing in accordance with ASTM and ISO standards, as follows:

• Cytotoxicity (L929 MEM Fibroblast)
• Sensitization (Kligman Maximization)
• Genotoxicity (Ames Mutagenicity and Micronucleus Assay)
• Implantation (90-Day Intramuscular and 6-Month Transcortical)
• Intracutaneous Reactivity (Intracutaneous Injection)
• Acute Toxicity (Systemic Injection and Pyrogenicity)
• Haemocompatibility (Hemolysis)

The results indicated that the OXINIUM material is at least as biocompatible as cobalt chrome and titanium alloy.