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Mechanism of Action

Did you know?

EXOGEN◊ is safe with metals in non-unions.⁹ Click here for more.

Helpful Links

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Guide to Casting

Using and applying EXOGEN◊

Reimbursement Support

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Only the EXOGEN◊ system uses LIPUS$%1%$ technology to stimulate a clear biological response at the cellular level

Osteoblasts are shown to respond to ultrasound stimulation as they begin to initiate the intracellular healing cascade.²

Osteoblasts are shown to respond to ultrasound stimulation

Only EXOGEN◊ Ultrasound has been proven to activate receptors called integrins, which are found on a wide range of cells crucial to bone healing^3,4

Research shows that EXOGEN◊ Ultrasound accelerates the body’s own healing processes at all stages of fracture healing$%5-8%$

EXOGEN◊ Ultrasound also upregulates proteins essential to bone repair: osteocalcin, osteonectin I, and osteopontin; other bone-healing enzymes, genes, and growth factors: alkaline phosphatase, MMP-13, and IGF-1²

References

Summary of Indications for Use

Proof of a Biologic Response

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