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CAPTION™

Disposable Platelet Concentrator

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What is PRC?

What is Platelet Rich Concentrate?

Answer:

Produced using the CAPTION^◊ system, platelets are suspended in saline and some residual plasma verses plasma alone.

Human mesenchymal stem cells (hMSCs) treated with CAPTION PRC (left). Alizarin red staining of the cells at 23 days shows significant bone mineralization compared to cells treated with serum alone (right).¹

Clinical References

_{1. (Smith & Nephew White Paper) Ellis K, Horner A. CAPTION^◊ Platelet Rich Concentrate (PRC) – effect on human mesenchymal stem cell differentiation and bone cell mineralization. 2007. Data on file at Smith & Nephew Group Research Centre}

How do platelets “jump start” the healing response?

Answer:

Upon injury to tissue, thrombin in the blood stream causes a fibrin mesh to form over an injured site. Platelets are trapped inside the mesh. Platelets become trapped in the mesh and release their growth factors. The mesh provides a scaffold for tissue repair.

How do platelets jump start the healing response?

3
How do platelets affect stem cells?
- Answer:
  
  Platelets release growth factors that aid in recruiting stem cells into a tissue repair site. Growth Factors also aid in stem cell differentiation.
  
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What are the growth factors?

Answer:

- Growth Factors help stem cells multiply and start to differentiate into new
   tissue cells i.e. bone, soft tissue, cartilage, skin, etc
- Growth Factors in platelets: PDGF, TGF-b, VEGF, IGF
- Growth factors stimulate:
     - Local blood flow and the growth of new blood vessels
     - Multiplication and differentiation of stem cells and repair cells

What are platelets?

Answer:

Platelets

   - Cell bodies 1-3 µm in diameter
   - Produced in the bone marrow from megakaryocytes
   - Circulates in the blood stream
   - Essential for blood clotting
   - Half-life of 10 days in the circulation

Contain 3 types of granules

   - Alpha granules contain growth
     factors (TGFb, PDGF-AB, and VEGF) and clotting factors
   - Lysosomes contain enzymes (acid hydrolases)