Silver is effective:

• used for centuries to prevent and treat infection
• powerful antimicrobial and bactericidal actions
• silver is a commonly used topical antimicrobial agent.

To be effective, silver must be available at concentrations in excess of the MIC and preferably the MBC.

MIC = Minimum Inhibitory concentration
MBC= Minimum Bactericidal concentration.

Minimum inhibitory concentration of ACTICOAT◊	MIC (µg/ml)
Staphylococcus aureus	12.5
Staphylococcus epidermidis	10.0
Eschericia coli	7.5
Klebsiella pneumoniae	5.0
Pseudomonas aeruginosa	7.5
Yin et al, J Burn Care and Rehabil.1999;20:195-2001

µg/ml = PPM

All active silver is ionic...

All silver products which are biologically active release ionic silver (Ag+).  Ionic silver must be in solution to be biologically active and able to act as an antimicrobial.

Nanocrystalline^† Silver...

• SILCRYST^™ Nanocrystals are the patented technology used by ACTICOAT^◊. SILCRYST^™ Nanocrystals are comprised of Nanocrystalline Silver.
• Nanocrystalline Silver is a revolutionary technology that provides a new class of Silver antimicrobial barrier protection.
• Nanocrystalline Silver releases silver ions faster than normal silver.
• Nanocrystalline Silver has increased antimicrobial activity.

Features of Nanocrystalline^† Silver...

Mode of Action of Nanocrystalline Silver...

The Nanocrystalline silver mediates the antimicrobial activity of ACTICOAT^◊.  When the dressing is moistened with sterile water or wound exudate, it activates the release of silver ions into solution where it provides antimicrobial activity within the dressing.

Moisture is required for the continual release of silver.

^™SILCRYST is a trademark of NUCRYST Pharmaceuticals Corp, used under license.
†Nanocrystalline Silver is a patented technology of NUCRYST Pharmaceuticals Corp