Email this page

Mandatory fields are marked with an asterisk [*].

Fill in your email details
1. * Your name:
2. * Your email address:
3. * Recipient name:
4. * Recipient email address:
Note: Smith & Nephew does not collect or make use of the email addresses or names provided here. They are only used to show the recipient who has sent the message.
Change the message if you want to
1. To: <recipient name> <address>
2. From: <sender name> <address>
3. Subject: <sender name> is sending you a link
4. Hi,
  I saw this on the Smith & Nephew site and thought you might be interested.
5. <sender name>
Visitor verfication
1. *Type the code shown

EXOGENSNTM

Ultrasound Bone Healing System

EXOGEN Downloads

EXOGEN Privacy Practices
(PDF - 65.34 KB)

EXOGEN Bone Healing System uses a mechanical force to stimulate mechanical receptors, producing a biological response

During the use of EXOGEN^◊ Bone Healing System, mechanical pressure waves transmit through skin and soft tissue. Cell receptors known as integrins are then activated, causing molecules to cluster. This clustering then starts an intra-cellular cascade during which molecules that regulate gene expression are stimulated and move into the nucleus to perform their function. This activity results in stimulated production of a range of genes and growth factors, which are critical to the bone healing process.

Mechanical pressure wave transmission
Mechanical pressure wave transmission

Integrin signal reception Integrin signal reception

Clustered integrins Clustered integrins

Molecules regulating gene expression are activated and migrate to the nucleus Molecules regulating gene expression are activated and migrate to the nucleus

Result: increased protein expression Result: increased protein expression