There is no known resistance of organisms to Iodine, which is a common problem with many bactericides. In addition to this Iodine has viricidal, fungicidal and amoebicidal properties that most other antiseptics do not possess.³

Iodine is presented at a high concentration (>1% free) it can be toxic to newly formed tissue within a wound e.g. fibroblasts².  However, IODOSORB^◊ has a concentration of 0.9% Cadexomer Iodine and studies have shown that at this concentration and complexed to cadexomer, there is no evidence that Iodosorb is toxic.  Moreover, the concentration gradient of iodine is formed with the lowest concentration of iodine at the wound surface and the greatest concentration away from the wound¹.  This slow release property and iodine concentration gradient have been thought to allow a non-toxic concentration of iodine to be maintained at the wound surface.

Cadexomer is a high molecular weight compound and will not be directly absorbed after application to wounds. It is, however, biologically degraded. As the Iodine is physically immobilized and not chemically complexed within the cadexomer particles¹.