| 1931 |
- Smith & Nephew (Pty) Ltd, Durban S.A. set up.
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| 1930 |
- Plaster of Paris bandages were launched (GYPSONA).
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| 1928 |
- The development of ELASTOPLAST began.
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| 1921 |
- The Canadian branch was established as a separate company.
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| 1914/1918 |
- Expansion to fulfill the needs of the war years led to staff numbers increasing from 50 to over 1,200.
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| 1906 |
- First overseas contracts were secured with Canadian Hospital Authorities.
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| 1896 |
- Horatio Nelson Smith, the founder's nephew, entered into partnership with his uncle and the firm became known as T.J. Smith and Nephew. He began to develop medical dressings.
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| 1856 |
- Thomas James Smith opened a pharmaceutical chemist shop in Hull, England.
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